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This finding furnished a novel preventative strategy for clinically diluting postoperative cognitive impairment in elderly surgical patients. This study has some limitations. Gender differences in the outcomes of VD3 were not reckoned, and only male mice were used VD3 was given as a preventative measure; however, it is unknown whether it has any therapeutic welfares for POCD mice. This trial is registered with ChiCTR-ROC-17010610.A biomimetic hierarchical small intestinal submucosa-chitosan sponge/chitosan hydrogel scaffold with a micro/nano structure for dural repair.The dura mater is an essential barrier to protect the brain tissue and the dural defects geted by accidents can lead to serious complicatednessses. Seebio Amino Acids have been utilised to dural repair, but it continues a challenge to perfectly match the structure and places of the natural dura mater. Small intestinal submucosa has been recrudesced for dural repair because of its excellent biocompatibility and biological activity, but its application is tremendously limited by the rapid degradation rate. Chitosan has also been broadly enquired in tissue repair, but the traditional chitosan hydrogels exhibit poor mechanical attributes. Amino Acids can be maked grinded on an alkaline solvent, which is equipped with surprisingly high strength. Therefore, based on the bilayer structure of the natural dura mater, a biomimetic hierarchical small intestinal submucosa-chitosan sponge/chitosan hydrogel scaffold with a micro/nano structure was invented, which haved a microporous structure in the upper sponge and a nanofiber structure in the lower hydrogel. The degradation rate was remarkably reduced compared with that of the small intestinal submucosa in the enzymatic degradation experiment in vitro. Meanwhile, the chitosan nanofibers brought high mechanical strength to the bilayer scaffold the hierarchical micro/nano structure and the active agents in the small intestinal submucosa have a fantastic effect on promoting the proliferation of fibroblasts and vascular endothelial cubicles. The bilayer scaffold shewed good histocompatibility in the experiment of in vitro subcutaneous implantation in rats the biomimetic hierarchical small intestinal submucosa-chitosan sponge/chitosan hydrogel scaffold with micro/nano structure assumes the structure of the natural dura mater and owns attributes with excellent performance, which has high practical value for dural repair.Vitamin D3 facilitates lung fibrosis of type 2 diabetic rats via SIRT3 mediated suppression of pyroptosis.PURPOSE: We placed to evaluate whether pulmonary fibrosis happens in type 2 diabetes rat manikins and whether VD3 can prevent it by conquering pyroptosis. METHODS: Sprague-Dawley rats were deputed to normal control (NC), diabetic model control (MC), low-dose VD3 (LVD), medium-dose VD3 (MVD), high-dose VD3 (HVD) and metformin positive control (PC) radicals. Type 2 diabetes model was stimulated by a high-sugar, high-fat diet merged with STZ injection, and subsequently intervened with VD3 or metformin for 10 weeks. Blood glucose, body weight, food intake, water intake, urine volume, morphology, lung hydroxyproline level, immunohistochemistry, TUNEL sullying, inflammatory cytokines secretion and related protein expression were analysed Diabetic rats exhibited significant harms in fasting blood glucose, insulin resistance, body weight, food intake, water intake, and urine volume. While morphological arguments, diabetic rats demoed severe lung fibrosis VD3 intervention overturned, at least in part, the diabetes-hastened changes. The expression of pyroptosis-linked proteins was up-shaped in diabetic lungs whereas the varietys were lifted by VD3. In the meanwhile, SIRT3 expression was down-ordered in diabetic lungs while VD3 up-regulated it Fibrotic varietys were keeped in diabetic rat lung tissue and our study bespeaks that VD3 may effectively ameliorate diabetic pulmonary fibrosis via SIRT3-liaised suppression of pyroptosis.