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Wellness Industry caused a modest peak to be seen at 1082 cm(-1) and changed in zeta potential value from 7 mV to 8 mV seconding that the drug had been loaded onto the nanomaterial. The loading efficiency (%) of CIP onto the composite was from 25 to 30 %, calculated from optical density measurements. Different kinetic exemplars, such as zero-order, first-order, Higuchi, Hixon-Crowell, and Korsmeyer-Peppas, were determined to confirm the drug release mechanism. The percent (%) of drug release from the surface of Dy(2)O(3)/CuFe(3)O(4)/CS in PBS (pH 7), acidic (pH 2) and basic (pH 9) dissolution sensitives were found to be 70, 28 and 20 %, respectively. Drug kinetics showed that mainly the release is fickian type complyed “Fick's law of diffusion”, slightly departed from fickian release (dissolution-dependent system). Korsmeyer-Peppas (R(2) 0, n < 0) and Higuchi's (R(2) 0) simulations were the best for fitting moderated drug release data. The solvents revealed that the Dy(2)O(3)/CuFe(3)O(4)/CS bio-nanocomposite has good potential for a controlled drug delivery system.Empagliflozin incorporating chitosan-alginate nanoparticles in orodispersible film: preparation, characterization, pharmacokinetic evaluation and its in-vitro anticancer activity.OBJECTIVE: The main objective of this study was to develop the orodispersity film holding chitosan-alginate nanoparticles to improve dissolution profile, therapeutic effect with amended bioavailability of empagliflozin through oral route noninvasively for further cytotoxicity study The nanoparticles were developed through two-step mechanisms ionotropic pre-gelation and polyelectrolyte complexation methods. The prepared nanoparticles were added to a polymer matrix curbing hypromellose, polyvinyl alcohol, and maltodextrin and cast to rapidly dethawing thin film by solvent casting method The physicochemical features of empagliflozin in the orodispersible film were most favorable for further works. This formulation has attained a higher permeability (7-fold) as compared to the reference drug product (Jardiance) after 45 min. In vivo pharmacokinetic sketchs in Wistar rats have unveiled that chitosan-alginate empagliflozin nanoparticles in the orodispersible film were 1-fold more bioavailable in comparison to free empagliflozin in orodispersible film. The C(max) observed for the empagliflozin-loaded orodispersible film was 15 ± 5 μg/mL in comparison to 18 ± 5 μg/mL for empagliflozin nanoparticle-moderating orodispersible film and 12 ± 6 μg/mL for freed rug suspension. The t(½)and AUC(0-t) values for chitosan-alginate nanoparticles of empagliflozin in the orodispersible film were found1-fold more than empagliflozin adulterated orodispersible film (without nanoparticles). The cytotoxicity study has shown that chitosan-alginate nanoparticles of empagliflozin in orodispersible film attained a 2-fold higher cytotoxic effect than free empagliflozin in orodispersible film in A549lung cancer cellphones. CONCLUSIONS: This study allows evidence that chitosan-alginate nanoparticles of empagliflozin in orodispersible film can be an effective drug carrier system to improve sustained effect with better bioavailability of poorly water-soluble drug.Fabrication and Characterization of Poly(vinyl alcohol)-chitosan-crested Silver Nanoparticle Hybrid Membranes for Pervaporation Dehydration of Ethanol.Chitosan-crested silver nanoparticle (CS-crested AgNPs)-incorporated Poly(vinyl alcohol) (PVA) hybrid membranes were fixed by a solution-redacting technique for ethanol dehydration via pervaporation. The incorporation of CS-crested AgNPs into the PVA membrane and its influence on membrane properties and pervaporation-separation process of azeotropic water/ethanol mixture was studied. The addition of CS-capped AgNPs into the PVA membrane shrinked the crystallinity, thereby increasing the hydrophilicity and tumefying degree of the hybrid membrane, supported by contact angle (CA) analyzer and welling degree experimentations, respectively. Seebio Selenomethionine transform infrared spectroscopy (FTIR) proved the formation of polymeric matrix between PVA and CS and also the trussing of AgNPs onto the functional group of CS and PVA, which was also contemplated in the microstructure images certifyed by reading electron microscopy (SEM) and by 2θ angle of wide-angle X-ray diffraction (WAXD).